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Plasma-Safe-SeqS
AML-MRD-SEQ

Reliable detection of AML-MRD relevant and promising mutations

AML-MRD-SEQ detects 68 mutations across 20 genes, including established AML markers, such as IDH1, IDH2, and NPM1, and it demonstrates a significant potential for use as an investigational tool for other markers with prognostic values that are not yet well established.

AML is one of the deadliest blood cancers, resulting in more than 10,000 lives lost in the U.S. each year.1 Because AML relapses usually result in a poor prognosis, it’s necessary to test patients for MRD after initial treatment as a prognostic indicator of therapeutic effectiveness and relapse risk. Using an ultra-sensitive test such as AML-MRD-SEQ to detect gene mutations associated with AML-MRD could help improve outcomes throughout the clinical trial process.

Panel features

CLIA-validated, ultra-sensitive blood test for the detection of BCOR, BRAF, CEBPA, FLT3, GATA2, IDH1, IDH2, JAK2, KIT, KRAS, NPM1, NRAS, PRPF8, PTPN11, SETBP1, SF3B1, SRSF2, TP53, U2AF1, and ZRSR2. This panel detects as few as 7 mutant molecules in a background of 20,000 wild-type molecules (0.035% mutant allele frequency).

GENE GENE REGIONS COVERED (AMINO ACIDS) CLINICAL RELEVANCE
FLT3 438-461, 479-493, 582-605, 663-684, 829-845 Established therapeutic indications, monitored for reduction/ clearance
IDH1 127-135, 256-281
IDH2 135-154, 171-178, 310-322
NPM1 260-275, 283-288 Established clinical validity for MRD
BCOR 333-358, 395-421, 577-605, 822-846, 1477-1489, 1513-1527, 1533-1555, 1636-1658 Prognostic markers typically detected with low sensitivity, qualitatively, at a single timepoint. Ultra-high sensitivity quantitative detection across multiple timepoints may reveal validity for MRD.
BRAF 582-604
CEBPA 61-86, 296-321
GATA2 301-329, 350-379, 382-400
JAK2 607-620
KIT 188-201, 412-425, 550-564, 808-828
KRAS 12-36, 57-76, 110-117, 141-148
NRAS 1-17, 55-70
PRPF8 674-692, 1574-1595, 1597-1611, 1743-1769
PTPN1 1 58-72
SETBP 1 856-877
SF3B1 622-644, 661-677, 699-722, 833-841
SRSF2 75-95
TP53 10-24, 26-32, 49-77, 99-125, 126-141, 151-179, 192-219, 225-248, 262-285, 297-306, 308-331, 332-360, 368-383
U2AF1 30-40, 146-159
ZRSR2 47-63, 69-71, 118-133, 171-185, 287-311
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