Panel features
CLIA-validated, ultra-sensitive blood test for the detection of BRAF, KRAS, NRAS, AKT1, and PIK3CA. This panel detects as few as 7 mutant molecules in a background of 20,000 wild-type molecules (0.035% mutant allele frequency).
GENE | EXON | EXAMPLES FOR COVERED ALTERATIONS WITH KNOWN CLINICAL RELEVANCE |
---|---|---|
AKT1 | 2 | E17K [c49G>A] |
BRAF | 6, 11, 15 | V600X [c1799T>A/C/G, c.1798_1799delinAA, c1798G>A/C/T and others] |
KRAS | 2, 3, 4 | G12X [c.35G>A/C/T, c.34G>A/C/T, c.34_35delinsTT and others] G13X [c.38G>A/C/T, c.37G>A/C/T, c.38_39delinsAT and others] G61X [c.183A>C/G/T, c.182A>C/G/T, c.181C>A/G and others] |
NRAS | 2, 3, 4 | G12X [c.35G>A/C/T, c.34G>A/C/T, c.34_35delinsAA and others] G13X [c.38G>A/C/T, c.37G>A/C/T, c.37_38delinsAA and others] Q61X [c.183A>C/G/T, c.182A>C/G/T, c.181C>A/G and others] |
PIK3CA | 1, 2, 4, 5, 7, 8, 9, 13, 18, 20 | C420R [c.1258T>C] E545X [c.1635G>A/C/T, c.1634A>C/G/T, c.1633G>A/C] M10431 [c.3129G>T], H1047X [c.3140A>G/T, c.3139G>T] |