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Plasma-Safe-SeqS
HPV-SEQ

Reliable detection and quantification of DNA for HPV 16 and 18

HPV-SEQ detects and quantifies cell-free HPV 16 and 18 DNA (cfHPV-DNA) across a large dynamic range and demonstrates accurate quantification even when few copies are present.

HPV-SEQ enables high-resolution molecular monitoring of patients with HPV-driven cancers.

Several studies are underway using HPV-SEQ to de-escalate HPV-driven cancer treatment to reduce toxicities without compromising survival outcomes. Assessment of quantitative cfHPV-DNA in the convenient biomarker-driven strategy to guide personalized treatment in HPV-positive oropharyngeal cancer (OPC).1

“The ability to reliably detect HPV-DNA in plasma at such low frequency shows HPV-SEQ could be a promising non-invasive biomarker test for effectively assessing treatment response, appropriately de-intensifying treatment using real-time dynamic HPV quantification, and monitoring HPV-positive OPC patients’ post-treatment. Therefore, the HPV-SEQ test has the potential to be an important tool for oncologists in treating patients with HPV-associated head and neck cancer,” he concluded.2

Dr. Nishant Agrawal,
Professor of Surgery at the University of Chicago.

Panel features

CLIA-validated, ultra-sensitive quantitative blood test for the detection of cell-free HPV 16 and 18 DNA (cfHPV-DNA, this panel detects as few as two HPV 16 and 18 molecules in a background of 30,000 wild-type molecules (0.03% allele frequency).

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References
  1. Rosenberg A, Izumchenko E, Pearson A, Gooi Z, et al. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment. BMC Cancer. 2022. 3;22(1):17. doi: 10.1186/s12885-021-09146-z.
  2. Sysmex Inostics Press Release, January 26, 2022