With more than 10 years of experience in liquid biopsy, Sysmex Inostics is propelling liquid biopsy solutions forward with a new next-generation sequencing-based assay: the Plasma-SeqSensei™ IVD* and RUO** kits.
Built on ultra-sensitive Plasma-Safe-SeqS technology, the new Plasma-SeqSensei™ kit portfolio detects and identifies mutations in various genes in human circulating cell-free DNA isolated from blood plasma.
Plasma-SeqSensei™ kits provide narrow panels with ultra-high sensitivity down to 0.06% mutant allele fractions (MAF) and absolute limit detection of 6 mutant molecules (MM) which is important for the clinical research purpose such as response monitoring, recurrence monitoring, and minimal residual disease detection.
*Currently only available in EMEA region.
**For research use only. Any in vitro diagnostics purpose has not been established by the manufacturer.
Unique Benefits
Highly sensitive
- Detects 0.06% and higher MAF with 95% certainty (in a background of 10,000 wildtype copies)
- Determines mutant molecules (MM) down to a limit of detection of 6 (independent of real sample DNA input)
Absolute quantification of samples using internal quantifier
Usage of UIDs (unique molecular identifiers)
- Reduces error reporting rate over 100-fold
Standardized workflow and high reproducibility
High flexibility and efficiency
- Processes 2 to 16 samples per run
- Pools multiple PSS RUO libraries in one run to save time and sequencing costs (not available for IVD kits)
Short turnaround time
- Takes ~2 days for 16 samples from DNA extraction to results (including sequencing time)
Easy-to-use and convenient Plasma-SeqSensei™ Software
- Integrates run-planning feature
- Provides sample variant call file, including validity checks for sample results
- Automates data analysis and generation of PDF-report per sample
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Oncology Panels
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Plasma-SeqSensei™
Solid Cancer IVD kit
Highly sensitive detection and identification of mutations in BRAF, EGFR, KRAS, NRAS and PIK3CA genes associated with development of solid cancer.
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Plasma-SeqSensei™
Breast Cancer IVD kit
Highly sensitive detection and identification of mutations in AKT1, ERBB2, ESR1, KRAS, PIK3CA and TP53 genes associated with development of breast cancer.
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Plasma-SeqSensei™
CRC RUO kit
Highly sensitive detection and identification of mutations in KRAS, NRAS, BRAF, and PIK3CA genes associated with colorectal cancer.
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Plasma-SeqSensei™
BC RUO kit
Highly sensitive detection and identification of mutations in AKT1, ERBB2, ESR1, KRAS, PIK3CA, and TP53 genes associated with breast cancer.
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Plasma-SeqSensei™
NSCLC RUO kit
Highly sensitive detection and identification of mutations in BRAF, EGFR, KRAS, and PIK3CA genes, which play a significant role in the development of NSCLC.
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Plasma-SeqSensei™
Melanoma RUO kit
Highly sensitive detection and identification of mutations in BRAF and NRAS oncogenes associated with melanoma development.
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Plasma-SeqSensei™
Thyroid RUO kit
Highly sensitive detection and identification of mutations in hotspot regions of BRAF and NRAS genes associated with thyroid cancer.
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