Our new Plasma-Safe-SeqS NGS technology can detect clinically relevant mutations in circulating tumor DNA (ctDNA) with sensitivity equivalent to our OncoBEAM digital PCR liquid biopsy from across a broader range of genomic regions.
OncoBEAM set the gold standard for ctDNA analysis as the most sensitive digital PCR approach available.(1) It has been used to detect subclonal resistance mutations, such as those in ESR1 for breast cancer patients on adjuvant aromatase inhibitor therapy who demonstrate endocrine resistance.(2)
With robust detection as low as 0.03%* mutant allele frequency (MAF), Plasma-Safe-SeqS ensures reliable molecular information for real-time therapy selection as well as monitoring of tumor response.
The data in the figure below shows the robust accuracy at low allelic frequencies observed for Plasma-Safe-SeqS and demonstrates the advantages of using focused panels for defined clinical purposes.(3)
*For input of 20,000 genomic equivalents
Plasma-Safe-SeqS sensitivity has 99.2% agreement with OncoBEAMTM
Ultra-sensitive Plasma-Safe-SeqS Panels
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